2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

Base Information

• Chemical Name: 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine
• CAS No.: 917482-61-2
• Molecular Formula: C₂₉H₃₆N₂O₆Si
• Molecular Weight: 536.7
• Mol file: 917482-61-2.mol

Synonyms:2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

Chemical Property of 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

There total 2 articles about 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2',3'-O,O-isopropylidene-5-methyluridine (2073-43-0) + tert-butylchlorodiphenylsilane (58479-61-1) → 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine (917482-61-2)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

5-Methyluridine (1463-10-1,642082-80-2) → 2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine (917482-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / p-toluenesulfonic acid monohydrate / acetone / 20 °C

2: 86 percent / imidazole; DMAP / dimethylformamide / 20 °C

With 1H-imidazole; dmap; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine (917482-61-2) → 5-bromomethyl-1-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; Heating;

DOI:10.1016/j.tetlet.2006.09.083

upstream raw materials:

2',3'-O,O-isopropylidene-5-methyluridine

tert-butylchlorodiphenylsilane

5-Methyluridine

Downstream raw materials:

5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine

5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine

5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

5-t-butyldiphenylsilyloxymethyl-5'-O-t-butyldiphenylsilyluridine 2',3'-bisxanthate