Technology Process of 1-(Phenylsulphonyl)-6-Methyl-7-azaindole
There total 5 articles about 1-(Phenylsulphonyl)-6-Methyl-7-azaindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
for 40h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm101027s
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 20 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere
3: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
4: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
With
tetrakis(triphenylphosphine) palladium(0); water; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
5: Negishi coupling reaction;
DOI:10.1021/jm101027s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere
2: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
3: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
With
tetrakis(triphenylphosphine) palladium(0); water; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
4: Negishi coupling reaction;
DOI:10.1021/jm101027s
