1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

Base Information

Chemical Name:1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone
CAS No.:452307-44-7
Molecular Formula:C₃₀H₃₁NO₃
Molecular Weight:453.581
Hs Code.:

Synonyms:1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

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Chemical Property of 1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

Chemical Property:

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Technology Process of 1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

There total 12 articles about 1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 452307-63-0
1-[7-hydroxy-10-(4-hydroxyphenyl)-5-methylphenanthren-2-yl]ethanone

: 452307-44-7
1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

Guidance literature:: 1-[7-hydroxy-10-(4-hydroxyphenyl)-5-methylphenanthren-2-yl]ethanone; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

N-chloroethylpiperidine hydrochloride; In N,N-dimethyl-formamide; at 40 - 50 ℃; for 2h;
DOI:10.1021/jm020536q

Reference yield:

: 874-63-5
3,5-dimethylmethoxybenzene

: 452307-44-7
1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 12 steps

1.1: HCl / 1,1,2,2-tetrachloro-ethane / 1 h / 17 °C

1.2: 61 percent / AlCl₃ / 1,1,2,2-tetrachloro-ethane / 3 h / 55 °C

2.1: 92 percent / NaOH / ethanol / 20 °C

3.1: Br₂ / CH₂Cl₂ / 20 °C

4.1: AcOH

5.1: 73 percent / DBU / tetrahydrofuran / 55 °C

6.1: 75 percent / 17 h / 190 °C

7.1: 48 g / AIBN; NBS / CCl₄ / 2 h / Heating

8.1: dimethylformamide / 5 h / 100 °C

9.1: 68.5 percent / aq. NaOH / CH₂Cl₂ / 3 h / 35 - 40 °C

10.1: CuBr / diethyl ether

10.2: 100 percent / aq. H₂SO₄ / diethyl ether

11.1: BBr₃ / CH₂Cl₂ / -60 - 3 °C

12.1: NaH / dimethylformamide / 0.17 h / 20 °C

12.2: dimethylformamide / 2 h / 40 - 50 °C

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); bromine; boron tribromide; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,1,2,2-tetrachloroethane; 9.1: Wittig reaction;
DOI:10.1021/jm020536q

Reference yield:

: 19447-00-8
4-methoxy-2,6-dimethylbenzylaldehyde

: 452307-44-7
1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 11 steps

1.1: 92 percent / NaOH / ethanol / 20 °C

2.1: Br₂ / CH₂Cl₂ / 20 °C

3.1: AcOH

4.1: 73 percent / DBU / tetrahydrofuran / 55 °C

5.1: 75 percent / 17 h / 190 °C

6.1: 48 g / AIBN; NBS / CCl₄ / 2 h / Heating

7.1: dimethylformamide / 5 h / 100 °C

8.1: 68.5 percent / aq. NaOH / CH₂Cl₂ / 3 h / 35 - 40 °C

9.1: CuBr / diethyl ether

9.2: 100 percent / aq. H₂SO₄ / diethyl ether

10.1: BBr₃ / CH₂Cl₂ / -60 - 3 °C

11.1: NaH / dimethylformamide / 0.17 h / 20 °C

11.2: dimethylformamide / 2 h / 40 - 50 °C

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); bromine; boron tribromide; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; 8.1: Wittig reaction;
DOI:10.1021/jm020536q