3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

Base Information

Chemical Name:3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol
CAS No.:1333171-20-2
Molecular Formula:C₁₆H₂₅F₃O₄Si
Molecular Weight:366.453
Hs Code.:

Synonyms:3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

Chemical Property:

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Technology Process of 3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

There total 3 articles about 3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1333171-19-9
{3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane

: 1333171-20-2
3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 4h; under 3102.97 Torr;
DOI:10.1021/jm200377r

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1333171-20-2
3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 21 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 18 h / 0 - 20 °C

3: 5%-palladium/activated carbon; hydrogen / ethanol; ethyl acetate / 4 h / 20 °C / 3102.97 Torr

With 1H-imidazole; di-isopropyl azodicarboxylate; 5%-palladium/activated carbon; hydrogen; triphenylphosphine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; benzene; 2: Mitsunobu reaction;
DOI:10.1021/jm200377r

Reference yield:

: 154458-56-7
1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(phenylmethoxy)-2-propanol

: 1333171-20-2
3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 18 h / 0 - 20 °C

2: 5%-palladium/activated carbon; hydrogen / ethanol; ethyl acetate / 4 h / 20 °C / 3102.97 Torr

With di-isopropyl azodicarboxylate; 5%-palladium/activated carbon; hydrogen; triphenylphosphine; In ethanol; ethyl acetate; benzene; 1: Mitsunobu reaction;
DOI:10.1021/jm200377r