{3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane

Base Information

• Chemical Name: {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane
• CAS No.: 1333171-19-9
• Molecular Formula: C₂₃H₃₁F₃O₄Si
• Molecular Weight: 456.577
• Mol file: 1333171-19-9.mol

Synonyms:{3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane

Chemical Property of {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane

There total 3 articles about {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-Trifluoromethoxyphenol (828-27-3) + 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(phenylmethoxy)-2-propanol (154458-56-7) → {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane (1333171-19-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 0 - 20 ℃; for 18h;

DOI:10.1021/jm200377r

Reference yield:

3-benzyloxypropan-1,2-diol (13071-59-5,17325-85-8,56552-80-8,4799-67-1) → {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane (1333171-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 21 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 18 h / 0 - 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; benzene; 2: Mitsunobu reaction;

DOI:10.1021/jm200377r

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → {3-benzyloxy-2-[4-trifluoromethoxyphenoxy]propoxy}tert-butyldimethylsilane (1333171-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 21 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 18 h / 0 - 20 °C

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; benzene; 2: Mitsunobu reaction;

DOI:10.1021/jm200377r

upstream raw materials:

3-benzyloxypropan-1,2-diol

4-Trifluoromethoxyphenol

1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(phenylmethoxy)-2-propanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-nitro-6-[4-trifluoromethoxyphenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

2-bromo-1-{3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]propyl}-4-nitro-1H-imidazole

tert-butyl{3-iodo-2-[4-trifluoromethoxyphenoxy]propoxy}dimethylsilane

3-{tert-butyldimethylsilyloxy}-2-[4-trifluoromethoxyphenoxy]-1-propanol