5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

Base Information

Chemical Name:5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine
CAS No.:1352803-26-9
Molecular Formula:C₂₈H₃₁FN₂O₂Si
Molecular Weight:474.65
Hs Code.:

Synonyms:5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

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Chemical Property of 5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

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Technology Process of 5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

There total 9 articles about 5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1417213-07-0
C₃₂H₄₁FLiN₃O₂Si

: 1352803-26-9
5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

Guidance literature:: With trifluoroacetic acid; at 23 ℃;

Reference yield: 55.0%

: 1352802-83-5
N,N-bis(4-methoxybenzyl)cyanamide

: 1352803-00-9
3-fluoro-5-(trimethylsilyl)benzaldehyde tert-butylimine

: 74-88-4
methyl iodide

: 1352803-26-9
5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

Guidance literature:: 3-fluoro-5-(trimethylsilyl)benzaldehyde tert-butylimine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -15 - 0 ℃; for 1.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1.25h; Inert atmosphere;

N,N-bis(4-methoxybenzyl)cyanamide; Further stages;
DOI:10.1002/anie.201104769

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1352803-26-9
5-fluoro-N,N-bis(4-methoxybenzyl)-7-(trimethylsilyl)isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylsulfinylmethanide / dimethyl sulfoxide; mineral oil / 0.67 h / 23 °C / Inert atmosphere

1.2: 16 h / 23 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -15 - 0 °C / Inert atmosphere

2.2: 1.25 h / -78 - 23 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; sodium methylsulfinylmethanide; In tetrahydrofuran; hexane; dimethyl sulfoxide; mineral oil;
DOI:10.1002/anie.201104769