(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

Base Information

Chemical Name:(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate
CAS No.:1035216-54-6
Molecular Formula:C₂₁H₁₉ClN₂O₄
Molecular Weight:398.846
Hs Code.:

Synonyms:(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

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Chemical Property of (Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

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Technology Process of (Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

There total 3 articles about (Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

: 1035215-64-5
4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzaldehyde

: 88738-78-7
bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

: 1035216-54-6
(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

Guidance literature:: With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 916596-04-8
3-chloro-4-isopropoxybenzonitrile

: 1035216-54-6
(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine / ethanol; water / 60 °C

2.1: N,N-dimethyl-formamide / 4.33 h / 110 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

3.2: -40 °C / Inert atmosphere

4.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With 18-crown-6 ether; hydroxylamine; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2315-81-3
2-chloro-4-cyanophenol

: 1035216-54-6
(Z)-methyl 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 60 °C

3.1: N,N-dimethyl-formamide / 4.33 h / 110 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

4.2: -40 °C / Inert atmosphere

5.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

With 18-crown-6 ether; di-tert-butyl-diazodicarboxylate; hydroxylamine; potassium hexamethylsilazane; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;