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3-chloro-4-isopropoxybenzonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 916596-04-8 Structure
  • Basic information

    1. Product Name: 3-chloro-4-isopropoxybenzonitrile
    2. Synonyms: 3-chloro-4-isopropoxybenzonitrile
    3. CAS NO:916596-04-8
    4. Molecular Formula:
    5. Molecular Weight: 195.648
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 916596-04-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-chloro-4-isopropoxybenzonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-chloro-4-isopropoxybenzonitrile(916596-04-8)
    11. EPA Substance Registry System: 3-chloro-4-isopropoxybenzonitrile(916596-04-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 916596-04-8(Hazardous Substances Data)

916596-04-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 916596-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,5,9 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 916596-04:
(8*9)+(7*1)+(6*6)+(5*5)+(4*9)+(3*6)+(2*0)+(1*4)=198
198 % 10 = 8
So 916596-04-8 is a valid CAS Registry Number.

916596-04-8Relevant articles and documents

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

De Fusco, Claudia,Brear, Paul,Iegre, Jessica,Georgiou, Kathy Hadje,Sore, Hannah F.,Hyv?nen, Marko,Spring, David R.

supporting information, p. 3471 - 3482 (2017/05/29)

Recently we reported the discovery of a potent and selective CK2α inhibitor CAM4066. This compound inhibits CK2 activity by exploiting a pocket located outside the ATP binding site (αD pocket). Here we describe in detail the journey that led to the discov

THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING

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Paragraph 0276, (2017/01/26)

The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.

OXADIAZOLE MODULATORS OF S1P METHODS OF MAKING AND USING

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Paragraph 0152, (2017/01/23)

The invention is directed to Compounds of Formula (I): wherein each variable is defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance for treating graft versus host disease and autoimmune diseases.

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists

Asano, Masayoshi,Nakamura, Tsuyoshi,Sekiguchi, Yukiko,Mizuno, Yumiko,Yamaguchi, Takahiro,Tamaki, Kazuhiko,Shimozato, Takaichi,Doi-Komuro, Hiromi,Kagari, Takashi,Tomisato, Wataru,Inoue, Ryotaku,Yuita, Hiroshi,Oguchi-Oshima, Keiko,Kaneko, Reina,Nara, Futoshi,Kawase, Yumi,Masubuchi, Noriko,Nakayama, Shintaro,Koga, Tetsufumi,Namba, Eiko,Nasu, Hatsumi,Nishi, Takahide

scheme or table, p. 3083 - 3088 (2012/06/04)

We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxadiazole ring is subjected to enterobacterial decomposition. As provisions for unpredictable issues, a series of alternative compounds were synthesized on the basis of compound 3. Extensive SAR studies led to the finding of 1,3-thiazole 24c with the EC50 value of 3.4 nM for human S1P1, and over 5800-fold selectivity against S1P3. In rat on host versus graft reaction (HvGR), the ID50 value of 24c was determined at 0.07 mg/kg. The pharmacokinetics in rat and monkey is also reported. Compared to compound 3, 24c showed excellent stability against enterobacteria.

NOVEL OXADIAZOLE COMPOUNDS

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Page/Page column 62, (2011/06/26)

Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o

NOVEL OXADIAZOLE COMPOUNDS

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Page/Page column 49-50, (2008/12/06)

Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o

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