methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate

Base Information

• Chemical Name: methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate
• CAS No.: 862372-14-3
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.265
• Mol file: 862372-14-3.mol

Synonyms:methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate

Chemical Property of methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

(R)-Methyl2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate

There total 10 articles about methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl iodide (74-88-4) + (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid (86123-95-7) → methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate (862372-14-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield: 87.3%

methyl (2Z)‐2‐[(tert‐butoxycarbonyl)imino]‐3‐methoxypropanoate → methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate (862372-14-3) + (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate (134167-07-0)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 60 ℃; under 15001.5 Torr;

Reference yield: 61.1%

trimethoxonium tetrafluoroborate (420-37-1) + 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester (95715-85-8) → methyl (R)-2-(tert-butoxycarbonylamino)-3-methoxypropanoate (862372-14-3)

Guidance literature:

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere; Green chemistry;

upstream raw materials:

(R)-N-tert-butoxycarbonyl serine

methyl iodide

di-tert-butyl dicarbonate

methyl (2R)-2-amino-3-methoxypropanoate hydrochloride

Downstream raw materials:

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid

tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate