2,4-DIPHENYLBENZOFURAN

Base Information

• Chemical Name: 2,4-DIPHENYLBENZOFURAN
• CAS No.: 863870-99-9
• Molecular Formula: C₂₀H₁₄O
• Molecular Weight: 270.331
• Mol file: 863870-99-9.mol

Synonyms:2,4-DIPHENYLBENZOFURAN

Chemical Property of 2,4-DIPHENYLBENZOFURAN

Chemical Property:

• PSA: 13.14000
• LogP: 5.76680

Purity/Quality:

99%min ^*data from raw suppliers

2,4-DIPHENYLBENZOFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIPHENYLBENZOFURAN

There total 6 articles about 2,4-DIPHENYLBENZOFURAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-bromo-2-phenylbenzo[b]furan (863870-92-2) + phenylboronic acid (98-80-6) → 2,4-diphenylbenzo[b]furan (863870-99-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 48h;

DOI:10.1021/jo0508402

Reference yield:

O-3-bromo-2-iodophenyl N,N-diethylcarbamate (863870-79-5) → 2,4-diphenylbenzo[b]furan (863870-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / NaOH / ethanol / Heating

2: 72 percent / piperidine; CuI / Pd(OAc)2(PPh₃)2 / dimethylformamide / 5 h / 60 °C

3: 72 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 48 h / 80 °C

With piperidine; sodium hydroxide; copper(l) iodide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(triphenylphosphine) palladium (Il) acetate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 3: Suzuki cross-coupling;

DOI:10.1021/jo0508402

Reference yield:

O-3-bromophenyl N,N-diethylcarbamate (863870-72-8) → 2,4-diphenylbenzo[b]furan (863870-99-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 84 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 89 percent / NaOH / ethanol / Heating

3.1: 72 percent / piperidine; CuI / Pd(OAc)2(PPh₃)2 / dimethylformamide / 5 h / 60 °C

4.1: 72 percent / Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 48 h / 80 °C

With piperidine; sodium hydroxide; copper(l) iodide; sodium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; water; N,N-dimethyl-formamide; 4.1: Suzuki cross-coupling;

DOI:10.1021/jo0508402

upstream raw materials:

4-bromo-2-phenylbenzo[b]furan

phenylboronic acid

O-3-bromophenyl N,N-diethylcarbamate

O-3-bromo-2-iodophenyl N,N-diethylcarbamate

Refernces