Technology Process of 2-(4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 7 articles about 2-(4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-(5,5-dimethyl-1,3-dioxan-2-yl)benzene;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -70 ℃;
for 0.333333h;
With
Trimethyl borate;
In
tetrahydrofuran; pentane;
at -70 - 20 ℃;
for 2.5h;
2,3-dimethyl-2,3-butane diol;
In
tetrahydrofuran; pentane;
at 20 ℃;
for 0.166667h;
Further stages.;
DOI:10.1039/b202407c
- Guidance literature:
-
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
under Ar; to a soln. of Br compd. at -75°C in THF a soln. of t-butyllithium in pentane was added slowly, after 20 min B compd. added, soln. allowed to warm to room temp. over 2.5 h, pinacol added, kept for 10 min; quenched with aq. CH3COOH, filtered (Celite, ether washing), filtrates evapd. under vac., residue dissolved in CHCl3/H2O, org. phase sepd. and washed with H2O, dried over Na2SO4, filtered, evapd. in vac., recrystd. from cyclohexane; elem. anal.;
DOI:10.1039/b202407c
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate;
In
1,4-dioxane;
Inert atmosphere;
Reflux;
DOI:10.1002/anie.201905591
