1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

Base Information

Chemical Name:1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate
CAS No.:736989-88-1
Molecular Formula:C₁₉H₂₈BNO₅
Molecular Weight:361.246
Hs Code.:

Synonyms:1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

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Chemical Property of 1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

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Technology Process of 1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

There total 6 articles about 1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

: 339185-70-5
1,1-dimethylethyl [2-(4-bromophenyl)-2-oxoethyl]carbamate

: 736989-88-1
1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

Guidance literature:: With potassium acetate; In 1,4-dioxane; at 90 ℃; for 16h; Inert atmosphere;

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 5467-72-1
α-amino-4-bromoacetophenone hydrochloride

: 73183-34-3
bis(pinacol)diborane

: 736989-88-1
1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

Guidance literature:: di-tert-butyl dicarbonate; α-amino-4-bromoacetophenone hydrochloride; With triethylamine; In 1,4-dioxane;

bis(pinacol)diborane; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane;
DOI:10.1021/acsmedchemlett.1c00391

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 736989-88-1
1,1-dimethylethyl {2-oxo-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylenetetramine / toluene / 16 h / 40 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / 20 - 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hexamethylenetetramine; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jm4013104