(2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

Base Information

Chemical Name:(2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate
CAS No.:178415-89-9
Molecular Formula:C₂₈H₃₆N₂O₆
Molecular Weight:496.604
Hs Code.:

Synonyms:(2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

Chemical Property:

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Technology Process of (2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

There total 3 articles about (2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: hunig's base (N,N-diisopropylethylamine)

: 776-74-9
Bromodiphenylmethane

: 174266-82-1
diethyl (2R,4R)-4-(tert-butyloxycarbonylamino)pyrrolidine-2,4-dicarboxylate

: 178415-89-9
(2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: In dichloromethane;

Reference yield:

: 174266-81-0
(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

: 178415-89-9
(2R,4R) diethyl-4-(tert-butyloxycarbonylamino)-1-(diphenylmethyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

2: i-Pr₂NEt₂ / CH₂Cl₂ / Ambient temperature

With i-Pr₂NEt₂; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00352-7