(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

Base Information

Chemical Name:(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate
CAS No.:174266-81-0
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

There total 8 articles about (2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 174266-80-9
diethyl (2R,4R)-1-benzyl-4-aminopyrrolidine-2,4-dicarboxylate

: 174266-81-0
(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

Guidance literature:: In dichloromethane; Ambient temperature;
DOI:10.1021/jm9601765

Reference yield:

: 132666-67-2
(2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate

: 174266-81-0
(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

2: 98 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 2 h / -78 °C

3: ethanol; H₂O / 48 h / 55 °C

4: 1.) aq. NaOH, 2.) SOCl₂ / 1.) reflux, overnight, 2.) reflux, 3 d

5: 100 percent / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; thionyl chloride; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm9601765

Reference yield:

: 100-39-0
benzyl bromide

: 174266-81-0
(2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

2: 98 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 2 h / -78 °C

3: ethanol; H₂O / 48 h / 55 °C

4: 1.) aq. NaOH, 2.) SOCl₂ / 1.) reflux, overnight, 2.) reflux, 3 d

5: 100 percent / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; thionyl chloride; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm9601765