N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine

Base Information

• Chemical Name: N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine
• CAS No.: 1311939-56-6
• Molecular Formula: C₂₂H₃₁N₅O₄
• Molecular Weight: 429.519
• Mol file: 1311939-56-6.mol

Synonyms:N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine

Chemical Property of N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine

There total 3 articles about N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C11H13N3 (159148-87-5) + 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine (207857-15-6) → N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine (1311939-56-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo2004007

Reference yield:

3-(imidazol-1-ylmethyl)benzonitrile (143426-59-9) → N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine (1311939-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: dichloromethane / 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

DOI:10.1021/jo2004007

Reference yield:

m-(bromomethyl)benzonitrile (28188-41-2) → N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine (1311939-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 0.5 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

3: dichloromethane / 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jo2004007

upstream raw materials:

C₁₁H₁₃N₃

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

3-(imidazol-1-ylmethyl)benzonitrile

m-(bromomethyl)benzonitrile