N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Base Information

Chemical Name:N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide
CAS No.:1380647-02-8
Molecular Formula:C₂₅H₂₇FN₆O₄
Molecular Weight:494.526
Hs Code.:

Synonyms:N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Suppliers and Price of N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

There total 7 articles about N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 32833-96-8
N,N-dimethyloxamic acid

: 1380647-01-7
10-amino-2-[4-[(4-fluorophenyl)methyl]-1H-imidazol-2-yl]-7,8,9,10-tetrahydro-3-hydroxy-7,10-ethanopyrimido[1,2-a]azepin-4(6H)-one

: 1380647-02-8
N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1188429-06-2
ethyl 10-(((benzyloxy)carbonyl)amino)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a] azepine-2-carboxylate

: 1380647-02-8
N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / ethanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

4: triethylamine / dichloromethane / 16 h / 20 °C

5: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

6: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

7: dmap; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With tetrachloromethane; dmap; formic acid; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₂₇H₂₆ClN₃O₅

: 1380647-02-8
N'-(2-(4-(4-fluorobenzyl)-1H-imidazol-2-yl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N,N-dimethylethanediamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: triphenylphosphine; tetrachloromethane / acetonitrile / 16 h / 45 °C

3: formic acid / palladium 10% on activated carbon / methanol / 3 h / 40 °C

4: dmap; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With tetrachloromethane; dmap; formic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;