1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester

Base Information

• Chemical Name: 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester
• CAS No.: 119126-25-9
• Molecular Formula: C₂₁H₂₁N₃O₇S
• Molecular Weight: 459.48

Synonyms:1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester

Chemical Property of 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester

Chemical Property:

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Technology Process of 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester

There total 3 articles about 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate (39562-16-8) → 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester (119126-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / sodium bicarbonate / dimethylformamide / 24 h / 70 °C

2: triethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydrogencarbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00286a020

Reference yield:

1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester (106720-60-9) + benzenesulfonyl chloride (98-09-9) → 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester (119126-25-9)

Guidance literature:

With triethylamine; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo00286a020

Reference yield:

→ 1,6-Dihydro-2-methoxy-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid, ethyl ester (119126-25-9)

Guidance literature:

upstream raw materials:

1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

benzenesulfonyl chloride

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

Downstream raw materials:

1,2,3,4-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid ethyl ester

2-amino-1,6-dihydro-4-methyl-6-(3-nitrophenyl)-1-(phenylsulfonyl)-5-pyrimidinecarboxylic acid ethyl ester

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