ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
• CAS No.: 123161-30-8
• Molecular Formula: C₃₀H₂₆FNO₅
• Molecular Weight: 499.539

Synonyms:ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Chemical Property of ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

There total 1 articles about ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-Carboxymethyl-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (123161-24-0) + diazodiphenylmethane (908093-98-1) → ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (123161-30-8)

Guidance literature:

In methanol; chloroform; Petroleum ether; Ambient temperature;

DOI:10.1248/cpb.42.2049

Reference yield: 94.0%

bis-(dimethylamino)methane (51-80-9) + ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (123161-30-8) → ethyl 1-cyclopropyl-7-(1-diphenylmethoxycarbonylvinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Guidance literature:

With acetic anhydride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1248/cpb.42.2049

Reference yield: 54.0%

1,5-Dibromo-3-methoxymethoxy-pentane + ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (123161-30-8) → 7-(1-Benzhydryloxycarbonyl-3-methoxymethoxy-cyclopentyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (164167-96-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 45 - 55 ℃; for 10h;

DOI:10.1248/cpb.42.2055

upstream raw materials:

7-Carboxymethyl-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

diazodiphenylmethane

Downstream raw materials:

ethyl 1-cyclopropyl-7-<1-diphenylmethoxycarbonyl-1,1-bis(hydroxymethyl)methyl>-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

7-(1-Benzhydryloxycarbonyl-3-benzyloxy-cyclobutyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

ethyl 7-(2-benzyloxymethyl-1-diphenylmethoxycarbonylcyclopropyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

7-(1-Benzhydryloxycarbonyl-3-methoxymethoxy-cyclopentyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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