{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

Base Information

Chemical Name:{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester
CAS No.:854022-31-4
Molecular Formula:C₄₁H₅₇N₃O₁₀Si
Molecular Weight:780.003
Hs Code.:

{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[<i>a</i>]phenanthren-6-yl)-1-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

Synonyms:{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

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Chemical Property of {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

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Technology Process of {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

There total 27 articles about {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-(8-allyloxy-6,6,9-trimethyl-3b,4,7a,12c-tetrahydro-1H-2,5,7,10,12-pentaoxa-3a-aza-dicyclopenta[a,l]phenanthren-3-yl)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-ethyl}-carbamic acid allyl ester

: 7677-24-9
trimethylsilyl cyanide

: {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

: 854022-31-4
{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -30 ℃;
DOI:10.1021/jo050408k

Reference yield:

: 854022-39-2
{2-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-1-formyl-ethyl}-carbamic acid allyl ester

: 854022-31-4
{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves 3 Angstroem / toluene / 40 °C

2: 590.0 mg / BF₃*OEt₂ / CH₂Cl₂ / -30 °C

With 3 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane; toluene;
DOI:10.1021/jo050408k

Reference yield:

: 854022-23-4
(S)-allyl 1-hydroxy-3-(3-tert-butyldimethylsilyloxy-4-methoxy-5-methylphenyl)propan-2-ylcarbamate

: 854022-31-4
{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 0 °C

2: molecular sieves 3 Angstroem / toluene / 40 °C

3: 590.0 mg / BF₃*OEt₂ / CH₂Cl₂ / -30 °C

With oxalyl dichloride; 3 A molecular sieve; boron trifluoride diethyl etherate; dimethyl sulfoxide; triethylamine; In dichloromethane; toluene; 1: Swern oxidation;
DOI:10.1021/jo050408k