2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

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Chemical Name:2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one
CAS No.:1394896-72-0
Molecular Formula:C₂₇H₂₀FN₅O₂S
Molecular Weight:497.553
Hs Code.:

Synonyms:2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

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Chemical Property of 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

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Technology Process of 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

There total 6 articles about 2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1394896-99-1
5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

: 105-36-2
ethyl bromoacetate

: 1394896-72-0
2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

Guidance literature:: In ethanol; for 1h; Reflux;
DOI:10.1016/j.jfluchem.2012.06.021

Reference yield:

: 1994-40-7
1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine

: 1394896-72-0
2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 5 h / 70 - 80 °C

2: sodium hydroxide / methanol / 24 h / 20 °C

3: sodium hydroxide / ethanol / 8 h / Reflux

4: ethanol / 1 h / Reflux

With sodium hydroxide; trichlorophosphate; In methanol; ethanol;
DOI:10.1016/j.jfluchem.2012.06.021

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1394896-72-0
2-(5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 1 h / Reflux

2: trichlorophosphate / 5 h / 70 - 80 °C

3: sodium hydroxide / methanol / 24 h / 20 °C

4: sodium hydroxide / ethanol / 8 h / Reflux

5: ethanol / 1 h / Reflux

With acetic acid; sodium hydroxide; trichlorophosphate; In methanol; ethanol;
DOI:10.1016/j.jfluchem.2012.06.021