(2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

Base Information

Chemical Name:(2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone
CAS No.:65367-73-9
Molecular Formula:C18H18 Br N O3
Molecular Weight:376.2444
Hs Code.:

Synonyms:Quinoline,1-(2-bromo-4,5-dimethoxybenzoyl)-1,2,3,4-tetrahydro- (9CI); NSC 271954

Suppliers and Price of (2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of (2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

Chemical Property:

Vapor Pressure:7.9E-11mmHg at 25°C
Boiling Point:517.9°Cat760mmHg
Flash Point:267°C
Density:1.401g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

There total 3 articles about (2-bromo-4,5-dimethoxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 55171-61-4
2-bromo-4,5-dimethoxybenzoyl chloride

: 65367-73-9
6-bromo-3,4-dimethoxy-N-tetrahydroquinolyl-benzamide

Guidance literature:: 1,2,3,4-tetrahydroisoquinoline; With triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

2-bromo-4,5-dimethoxybenzoyl chloride; In dichloromethane; toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol3019677

Reference yield:

: 6286-46-0
2-bromo-4,5-dimethoxybenzoic acid

: 65367-73-9
6-bromo-3,4-dimethoxy-N-tetrahydroquinolyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.92 h / 0 - 80 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol3019677