4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole

Base Information

• Chemical Name: 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole
• CAS No.: 1403581-45-2
• Molecular Formula: C₂₂H₂₃N₃O₆
• Molecular Weight: 425.441

Synonyms:4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole

Chemical Property of 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole

Chemical Property:

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Technology Process of 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole

There total 2 articles about 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-1H-benzo[d]imidazole-7-yl) oxazole (1403581-29-2) + 2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) → 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N1-hydroxyethylbenzo[d]imidazole-7-yl)oxazole (1403581-45-2) + 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N1-hydroxyethylbenzo[d]imidazole-4-yl)oxazole (1403581-46-3)

Guidance literature:

4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-1H-benzo[d]imidazole-7-yl) oxazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-(tert-butyldimethylsilyloxy)ethyl bromide; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2013.08.006

Reference yield:

4-methoxy-7-carbaldehyde-N1-1H-benzo[d]imidazole (1403581-61-2) → 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N1-hydroxyethylbenzo[d]imidazole-7-yl)oxazole (1403581-45-2) + 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N1-hydroxyethylbenzo[d]imidazole-4-yl)oxazole (1403581-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 25 h / 20 °C / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 6 h / 60 °C

2.3: 0.5 h / 20 °C

With sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.08.006

upstream raw materials:

4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-1H-benzo[d]imidazole-7-yl) oxazole

2-(tert-butyldimethylsilyloxy)ethyl bromide

4-methoxy-7-carbaldehyde-N¹-1H-benzo[d]imidazole

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