1403581-29-2

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 27080-53-1 4-methoxy-1H-benzo[d]imidazole 
• 37466-89-0 3-methoxybenzene-1,2-diamine 
• 16554-45-3 2-methoxy-6-nitroaniline 
• 1403581-61-2 4-methoxy-7-carbaldehyde-N¹-1H-benzo[d]imidazole 
• 324519-54-2 5-{isocyano[(4-methylphenyl)sulfonyl]methyl}-1,2,3-trimethoxybenzene 

Downstream Products

• 1403581-33-8 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methoxycarbonylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-34-9 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-methoxycarbonylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-35-0 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-carbethoxymethylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-36-1 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-carbethoxymethylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-39-4 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-cyanomethylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-40-7 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-cyanomethylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-45-2 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-hydroxyethylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-46-3 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-hydroxyethylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-47-4 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-hydroxypropylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-48-5 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-hydroxypropylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-37-2 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-carboxymethylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-38-3 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N-carboxymethylbenzo[d]imidazole-4-yl)oxazole 
• 1403581-41-8 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-carbamoylmethylbenzo[d]imidazole-7-yl)oxazole 
• 1403581-42-9 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N¹-carbamoylmethylbenzo[d]imidazole-4-yl)oxazole 

Relevant academic research and scientific papers

Synthesis and antiproliferative evaluation of novel benzoimidazole- contained oxazole-bridged analogs of combretastatin A-4

A series of novel oxazole-bridged analogs of combretastatin A-4 bearing a benzo[d]-imidazole as B ring were synthesized and evaluated for antiproliferative activities against five human cancer cell lines. Among all the synthesized compounds, the N-unsubstituted benzoimidazole analog 5 and the analogs 6b, 7a and 7b with a small hydrophobic group on nitrogen atom of benzoimidazole ring were identified as the most potent inhibitors of tumor cell growth with IC50 values at nanomolar levels (5, IC50 = 8.4 nM, HT29; 6b, 7a, 7b, IC50 = 9.6 nM, 3.8 nM, 3.0 nM, A549). In a murine H22 tumor xenograft model, compound 5 exhibited significant antitumor activity. The binding mode of compound 5 in the colchicine binding site of tubulin was probed.