methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

Base Information

Chemical Name:methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate
CAS No.:578020-83-4
Molecular Formula:C₂₀H₂₂O₇
Molecular Weight:374.39
Hs Code.:

Synonyms:methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

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Chemical Property of methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

Chemical Property:

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Technology Process of methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

There total 4 articles about methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 578020-81-2
methyl [5-(dimethoxymethyl)-2-methoxyphenyl]acetate

: 578020-83-4
methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

Guidance literature:: With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 0.5h;
DOI:10.1002/hlca.200390036

Reference yield:

: 93-25-4
2-methoxyphenylacetic acid

: 578020-83-4
methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / SOCl₂ / 1 h / 0 °C

2: 98 percent / SnCl₄ / CH₂Cl₂ / 1.5 h / 20 °C

3: 88 percent / NH₄Cl / methanol / 2 h / Heating

4: 77 percent / LDA / diethyl ether / 0.5 h / -78 °C

With thionyl chloride; tin(IV) chloride; ammonium chloride; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; 2: Rieche formylation;
DOI:10.1002/hlca.200390036

Reference yield:

: 27798-60-3
methyl 2-(2-methoxyphenyl)acetate

: 578020-83-4
methyl 3-(3,4-dimethoxyphenyl)-2-(5-formyl-2-methoxyphenyl)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / SnCl₄ / CH₂Cl₂ / 1.5 h / 20 °C

2: 88 percent / NH₄Cl / methanol / 2 h / Heating

3: 77 percent / LDA / diethyl ether / 0.5 h / -78 °C

With tin(IV) chloride; ammonium chloride; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; 1: Rieche formylation;
DOI:10.1002/hlca.200390036