(S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine

Base Information

• Chemical Name: (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine
• CAS No.: 1309686-87-0
• Molecular Formula: C₃₂H₄₀N₂O₃Si
• Molecular Weight: 528.767

Synonyms:(S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine

Chemical Property of (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine

Chemical Property:

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Technology Process of (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine

There total 2 articles about (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (848821-58-9) → (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine (1309686-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene-d6 / 25 °C / Molecular sieve; Inert atmosphere

2: 4-nitro-benzoic acid / toluene / 24 h / 25 °C / Inert atmosphere

With 4-nitro-benzoic acid; In benzene-d6; toluene;

DOI:10.1002/hlca.201300079

Reference yield:

(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (848821-58-9) + nitrostyrene (5153-67-3) + isobutyraldehyde (78-84-2) → (S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine (1309686-87-0)

Guidance literature:

In ⁽²⁾H₈-toluene;

DOI:10.1021/ja203660r

Reference yield:

(S)-1-((1S,3R,4S)-2,2-dimethyl-4-nitro-3-phenylcyclobutyl)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine (1309686-87-0) + propionaldehyde (123-38-6) → (2S)-(diphenyl((trimethylsilyl)oxy)methyl)-1-((1'S,2'R,3'S,4'S)-2'-methyl-4'-nitro-3'-phenylcyclobutyl)pyrrolidine (1309664-91-2) + isobutyraldehyde (78-84-2)

Guidance literature:

In ⁽²⁾H₈-toluene; Molecular sieve;

DOI:10.1021/ja203660r

upstream raw materials:

(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine

nitrostyrene

isobutyraldehyde

Downstream raw materials:

(2S)-(diphenyl((trimethylsilyl)oxy)methyl)-1-((1'S,2'R,3'S,4'S)-2'-methyl-4'-nitro-3'-phenylcyclobutyl)pyrrolidine

isobutyraldehyde

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