(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Base Information

Chemical Name:(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole
CAS No.:77661-89-3
Molecular Formula:C₁₆H₂₂O₃
Molecular Weight:262.349
Hs Code.:

Synonyms:(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Suppliers and Price of (3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Chemical Property:

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Technology Process of (3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

There total 3 articles about (3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7686-77-3
3-cyclopentene-1-carboxylic acid

: 77661-89-3
(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaClO₃, NaHCO₃, OsO₄; 2.) and 3) conc. H₂SO₄ / 1.) H₂O, 70 deg C, 11 h; 2.) reflux; 3.) reflux, 1 h

2: 92 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

3: 1.) NaH / 1.) DMF; 2.) 2h, 0 deg C, then room temp.

With sodium chlorate; osmium(VIII) oxide; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1021/jo00329a011

Reference yield:

: 77714-60-4
methyl c-3,c-4-isopropylidenedioxy-r-1-cyclopentanecarboxylate

: 77661-89-3
(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

2: 1.) NaH / 1.) DMF; 2.) 2h, 0 deg C, then room temp.

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00329a011

Reference yield:

: 100-39-0
benzyl bromide

: 77661-88-2
c-3,c-4-isopropylidenedioxy-r-1-cyclopentylmethanol

: 77661-89-3
(3aR,5R,6aS)-5-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF; 2.) 2h, 0 deg C, then room temp.;
DOI:10.1021/jo00329a011