5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one

Base Information

• Chemical Name: 5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one
• CAS No.: 718619-69-3
• Molecular Formula: C₁₄H₇F₃IN₃O₂
• Molecular Weight: 433.128

Synonyms:5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one

Chemical Property of 5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one

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Technology Process of 5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one

There total 1 articles about 5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-amino{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carboxamide; 2-(4-iodo-2-fluoro-phenylamino)-3,4-difluoro-benzoic acid hydrazide (718619-66-0) + 1,1'-carbonyldiimidazole (530-62-1) → 5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one (718619-69-3)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 20 ℃; for 5h;

Reference yield: 99.6%

5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one (718619-69-3) + (2-aminoethyl)methylcarbamic acid tert-butyl ester (121492-06-6) → 4'-(2-amino-ethyl)-methyl-carbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole (718619-71-7)

Guidance literature:

In ethanol; for 16h; Heating / reflux;

Reference yield: 97.2%

5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-3H-[1,3,4]oxadiazol-2-one (718619-69-3) + ethanolamine (141-43-5) → 4'-(2-amino-ethanol)-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole (718619-74-0)

Guidance literature:

In ethanol; for 16 - 20h; Heating / reflux;

upstream raw materials:

N-amino{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carboxamide; 2-(4-iodo-2-fluoro-phenylamino)-3,4-difluoro-benzoic acid hydrazide

1,1'-carbonyldiimidazole

Downstream raw materials:

C₁₇H₁₆F₃IN₄O₄

4'-N-ethylcarbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

C₁₇H₁₆F₃IN₄O₄

4'-(2-amino-ethyl)-methyl-carbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

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