2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

Base Information

Chemical Name:2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid
CAS No.:1242846-25-8
Molecular Formula:C₂₅H₂₃F₄NO₅S
Molecular Weight:525.521
Hs Code.:

Synonyms:2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

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Chemical Property of 2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

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Technology Process of 2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

There total 9 articles about 2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₁F₄NO₅S

: 1242846-25-8
2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 23877-12-5
tert-butyl bromoisobutyrate

: 1242846-79-2
N-(3-(3-trifluoromethylphenyl)-4-hydroxybenzyl)-4-fluoro-N-methylbenzenesulfonamide

: 1242846-25-8
2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

Guidance literature:: tert-butyl bromoisobutyrate; N-(3-(3-trifluoromethylphenyl)-4-hydroxybenzyl)-4-fluoro-N-methylbenzenesulfonamide; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1242846-25-8
2-(2-(3-trifluoromethylphenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

2: methanol / 0.5 h / 20 °C

3: sodium tetrahydroborate; methanol / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 90 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

8: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; sodium tetrahydroborate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;