N-(2-phenylethyl)butanamide

Base Information

• Chemical Name: N-(2-phenylethyl)butanamide
• CAS No.: 6283-13-2
• Molecular Formula: C12H17 N O
• Molecular Weight: 191.273
• Mol file: 6283-13-2.mol

Synonyms:Butyramide,N-phenethyl- (6CI,7CI,8CI); N-Phenethylbutyramide; NSC 7139

Chemical Property of N-(2-phenylethyl)butanamide

Chemical Property:

• Vapor Pressure: 1.24E-05mmHg at 25°C
• Boiling Point: 368.8°C at 760 mmHg
• Flash Point: 220.6°C
• Density: 0.984g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-phenylethyl)butanamide

There total 12 articles about N-(2-phenylethyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenethylamine (64-04-0) + butyryl chloride (141-75-3) → N-(2-phenylethyl)butanamide (6283-13-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 30 ℃; for 12h;

DOI:10.1021/acs.orglett.7b01274

Reference yield: 94.0%

2,2,2-trichloroethyl butyrate (57392-44-6) + phenethylamine (64-04-0) → N-(2-phenylethyl)butanamide (6283-13-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1139/cjc-2018-0234

Reference yield: 85.0%

butyl butyrate (109-21-7) + phenethylamine (64-04-0) → N-(2-phenylethyl)butanamide (6283-13-2)

Guidance literature:

With C₃₁H₄₀MnN₂O₃P*C₆H₁₄O; potassium tert-butylate; In toluene; 1,3,5-trimethyl-benzene; at 110 ℃; for 48h; Schlenk technique;

DOI:10.1002/anie.201709180

upstream raw materials:

phenethylamine

butyryl chloride

butyric acid

butyraldehyde oxime

Downstream raw materials:

1-propylisoquinoline

N-Butyl-2-phenylethylamine

Refernces

• 1、 Meschwitz, Susan M.,Teasdale, Margaret E.,Mozzer, Ann,Martin, Nicole,Liu, Jiayuan,Forschner-Dancause, Stephanie,Rowley, David C.. "Antagonism of quorum sensing phenotypes by analogs of the marine bacterial secondary metabolite 3-methyl-N-(20-phenylethyl)-butyramide". . . Retrieved 2019/07/15.
• 2、 La, Minh Thanh,Kim, Hee-Kwon. "Facile direct synthesis of amides from trichloroethyl esters using catalytic DBU". . p. 1135 - 1141. Retrieved 2018/11/25.