(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

Base Information

Chemical Name:(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid
CAS No.:1401985-61-2
Molecular Formula:C₂₄H₂₃N₅O₂S
Molecular Weight:445.545
Hs Code.:

Synonyms:(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

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Chemical Property of (S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

There total 6 articles about (S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine

: 851956-01-9
(S)-(+)-3-piperidinecarboxylic acid hydrochloride

: 1401985-61-2
(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

Guidance literature:: 2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine; (S)-(+)-3-piperidinecarboxylic acid hydrochloride; With N-ethyl-N,N-diisopropylamine; In butyrolnitrile; at 110 ℃; Industry scale;

With sodium hydroxide; In butyrolnitrile; water; at 20 ℃; pH=10; Industry scale;

Reference yield:

: 76872-75-8
5-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 1401985-61-2
(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: P,P-dichlorophenylphosphine oxide / 25 h / 20 - 150 °C

2.1: triethylamine / ethanol / 3 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / butyrolnitrile / 110 °C / Industry scale

3.2: 20 °C / pH 10 / Industry scale

With P,P-dichlorophenylphosphine oxide; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; butyrolnitrile;

Reference yield:

: 76872-27-0
2,4-dichloro-5-phenyl-thieno[2,3-d]pyrimidine

: 1401985-61-2
(S)-1-{5-phenyl-4-[(pyridin-2-ylmethyl)amino]thieno[2,3-d]pyrimidin-2-yl}piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 3 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / butyrolnitrile / 110 °C / Industry scale

2.2: 20 °C / pH 10 / Industry scale

With triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; butyrolnitrile;