Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester
CAS No.:132469-06-8
Molecular Formula:C₃₇H₅₁N₂O₇P
Molecular Weight:666.795
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

There total 6 articles about Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 92611-10-4
bis(N,N-diisopropylamino)methoxyphosphine

: 131261-78-4
4-{(2S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-butyramide

: 132469-06-8
Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: With (i-Pr₂N)2NH*tetrazol; In dichloromethane;
DOI:10.1016/S0040-4039(00)97060-6

Reference yield:

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 132469-06-8
Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Mg / 1) I₂ / 1) ether, 2) 3 h, room temp.

2: 72 percent / O₃, HCl / 1) -78 deg C, 2) to 0 deg C

3: conc. NH₃

4: pyridine

5: 65 percent / (i-Pr₂N)2NH*tetrazol / CH₂Cl₂

With pyridine; hydrogenchloride; ammonium hydroxide; (i-Pr₂N)2NH*tetrazol; ozone; magnesium; iodine; In dichloromethane;
DOI:10.1016/S0040-4039(00)97060-6

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 132469-06-8
Diisopropyl-phosphoramidous acid (2R,3S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(3-carbamoyl-propyl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 65 percent / (i-Pr₂N)2NH*tetrazol / CH₂Cl₂

With pyridine; (i-Pr₂N)2NH*tetrazol; In dichloromethane;
DOI:10.1016/S0040-4039(00)97060-6