4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

Base Information

Chemical Name:4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3
CAS No.:190833-99-9
Molecular Formula:C₃₇H₄₆ClN₃O₈S
Molecular Weight:728.307
Hs Code.:

Synonyms:4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

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Chemical Property of 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

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Technology Process of 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

There total 5 articles about 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1611-03-6
3,5-di-tert-butyl-4-hydroxyphenyl acetic acid

: 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-Lys-OCH₃ hydrochloride

: 190833-99-9
4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 20h;
DOI:10.1021/jm960772z

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 190833-99-9
4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 70percent aq. HClO₄

2: 72 percent / Et₃N, HOBT, DCC / dimethylformamide / 20 h

With perchloric acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm960772z

Reference yield:

: 27894-50-4
methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

: 190833-99-9
4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-N-ε-[(4-hydroxy-3,5-di-tert-butylphenyl)acetyl]-Lys-OCH3

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / BOP, DIEA / dimethylformamide / 18 h / Ambient temperature

2: HBr, AcOH / 4 h

3: 72 percent / Et₃N, HOBT, DCC / dimethylformamide / 20 h

With hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm960772z