3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone

Base Information

• Chemical Name: 3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone
• CAS No.: 1256700-45-4
• Molecular Formula: C₂₂H₃₇F₃O₃Si₂
• Molecular Weight: 462.7
• Mol file: 1256700-45-4.mol

Synonyms:3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone

Chemical Property of 3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone

There total 1 articles about 3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl trifluoroacetate, (383-63-1) + (((5-iodo-1,3-phenylene)bis(methylene))bis(oxy))bis(tert-butyldimethylsilane) (1111715-86-6) → 3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone (1256700-45-4)

Guidance literature:

(((5-iodo-1,3-phenylene)bis(methylene))bis(oxy))bis(tert-butyldimethylsilane); With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; at -78 ℃; for 1.25h;

DOI:10.1039/c0cc02450c

Reference yield:

3',5'-bis(tert-butyldimethylsilyloxymethyl)-2,2,2-trifluoromethylacetophenone (1256700-45-4) → C22H38F3NO2Si2

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; at 60 ℃;

DOI:10.1039/c0cc02450c

upstream raw materials:

ethyl trifluoroacetate,

(((5-iodo-1,3-phenylene)bis(methylene))bis(oxy))bis(tert-butyldimethylsilane)