1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

Base Information

Chemical Name:1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea
CAS No.:1455037-95-2
Molecular Formula:C₂₃H₂₄ClFN₄O
Molecular Weight:426.921
Hs Code.:

Synonyms:1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

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Chemical Property of 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

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Technology Process of 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

There total 8 articles about 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1455037-87-2
1-cycloheptyl-3-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455037-95-2
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 60 ℃; for 3h; Inert atmosphere;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455037-95-2
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

6: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

7: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1001756-21-3
4-amino-6-chloropyridine-3-carboxaldehyde

: 1455037-95-2
1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-cycloheptylurea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;