5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Base Information

Chemical Name:5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol
CAS No.:101712-92-9
Molecular Formula:C₂₆H₂₄ClF₂N₃O
Molecular Weight:467.946
Hs Code.:

Synonyms:5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Suppliers and Price of 5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Chemical Property:

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Technology Process of 5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

There total 8 articles about 5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 101712-92-9
5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium acetate

2: iron, ferric chloride hexahydrate, hydrochloric acid / H₂O

3: 52 percent / aq. sodium hydroxide / ethanol / 20 h

4: H₂ / Raney nickel / methanol

5: methanol

6: ethanol; H₂O / Heating

7: 6 N aq. HCl / Heating

8: ethanol / Heating

With ammonium acetate; hydrogenchloride; sodium hydroxide; hydrogen; iron(III) chloride; iron; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00156a009

Reference yield:

: 101712-20-3
1-(2,6-Difluoro-phenyl)-propan-2-one

: 101712-92-9
5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / aq. sodium hydroxide / ethanol / 20 h

2: H₂ / Raney nickel / methanol

3: methanol

4: ethanol; H₂O / Heating

5: 6 N aq. HCl / Heating

6: ethanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00156a009

Reference yield:

: 157224-28-7
1,3-Difluoro-2-((E)-2-nitro-propenyl)-benzene

: 101712-92-9
5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-2',6'-difluoro-biphenyl-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: iron, ferric chloride hexahydrate, hydrochloric acid / H₂O

2: 52 percent / aq. sodium hydroxide / ethanol / 20 h

3: H₂ / Raney nickel / methanol

4: methanol

5: ethanol; H₂O / Heating

6: 6 N aq. HCl / Heating

7: ethanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; iron(III) chloride; iron; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00156a009