(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
CAS No.:174840-08-5
Molecular Formula:C₂₄H₂₈BrCl₂NO₆
Molecular Weight:577.299
Hs Code.:

Synonyms:(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Suppliers and Price of (S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

There total 4 articles about (S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 174840-07-4
(R)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: With pyridinium hydrobromide perbromide; In dichloromethane; at -20 ℃;

Reference yield:

: 164263-08-5
(R)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran / 18 h

2: pyridinium bromoperbromide / CH₂Cl₂ / 1 h / -20 °C

With dmap; pyridinium perbromide hydrobromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.45.869

Reference yield:

: 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butoxycarbonylmethyl ester 5-(2,2-dimethyl-propionyloxymethyl) ester

: 174840-08-5
(S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lipase AH / cyclohexane / 95 h / Ambient temperature

2: dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran / 18 h

3: pyridinium bromoperbromide / CH₂Cl₂ / 1 h / -20 °C

With dmap; pyridinium perbromide hydrobromide; lipase AH; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1248/cpb.45.869