4-cyano-2,2-dimethylbutyric acid benzylamide

Base Information

• Chemical Name: 4-cyano-2,2-dimethylbutyric acid benzylamide
• CAS No.: 1644290-76-5
• Molecular Formula: C₁₄H₁₈N₂O
• Molecular Weight: 230.31
• Mol file: 1644290-76-5.mol

Synonyms:4-cyano-2,2-dimethylbutyric acid benzylamide

Chemical Property of 4-cyano-2,2-dimethylbutyric acid benzylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-cyano-2,2-dimethylbutyric acid benzylamide

There total 2 articles about 4-cyano-2,2-dimethylbutyric acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-benzyl-α-bromoisobutyranilide (60110-37-4) + acrylonitrile (107-13-1,25014-41-9) → 4-cyano-2,2-dimethylbutyric acid benzylamide (1644290-76-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); sodium cyanoborohydride; In tert-butyl alcohol; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201402441

Reference yield: 18.0%

N-benzyl-α-bromoisobutyranilide (60110-37-4) + acrylonitrile (107-13-1,25014-41-9) → N-benzylisobutyramide (4774-58-7) + 4-cyano-2,2-dimethylbutyric acid benzylamide (1644290-76-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); sodium cyanoborohydride; In tert-butyl alcohol; at 80 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/ejoc.201402441

upstream raw materials:

N-benzyl-α-bromoisobutyranilide

acrylonitrile