60110-37-4

Basic information

• Product Name: N-benzyl-2-broMo-2-MethylpropanaMide
• Synonyms: N-benzyl-2-broMo-2-MethylpropanaMide
• CAS NO: 60110-37-4
• Molecular Formula: C₁₁H₁₄BrNO
• Molecular Weight: 256.13896
• Mol File: 60110-37-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 71-72 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 383.3°C at 760 mmHg
• Flash Point: 185.6°C
• Appearance: /
• Density: 1.341g/cm³
• Vapor Pressure: 4.43E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• PKA: 14.94±0.46(Predicted)
• CAS DataBase Reference: N-benzyl-2-broMo-2-MethylpropanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-broMo-2-MethylpropanaMide(60110-37-4)
• EPA Substance Registry System: N-benzyl-2-broMo-2-MethylpropanaMide(60110-37-4)

Safety Data

• Hazardous Substances Data: 60110-37-4(Hazardous Substances Data)

Usage

General Description

N-benzyl-2-bromo-2-methylpropanamide is a chemical compound that has a molecular formula of C14H18BrNO. This chemical is categorized under benzenoids, carboxylic acids and derivatives, and it belongs to the family of Benzoyl compounds. The molecule contains a benzyl group which is connected to an amide group. Furthermore, it involves a bromine atom, thus placing it within the class of organobromides and its derivative is methine. It is commonly used in chemical and pharmaceutical research. As a research chemical, it is not intended for consumption or medical use. Further information about its physical properties and safety hazards is typically provided by suppliers and may vary.

InChI:InChI=1/C11H14BrNO/c1-11(2,12)10(14)13-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,13,14)

Upstream product

• 100-46-9 benzylamine 
• 20469-89-0 2-bromo-2-methylpropionyl chloride 
• 20769-85-1 2-bromoisobutyric acid bromide 
• 2052-01-9 2-bromo-2-methylpropionic acid 

Downstream Products

• 3219-55-4 N-benzylmethacrylamide 
• 115539-44-1 4-benzyl-2,2-dimethyl-1-oxa-4,6-diazaspiro<4,5>decan-3-one 
• 78877-71-1 3-Benzyl-2-benzylamino-2-isopropenyl-5,5-dimethyl-oxazolidin-4-one 
• 75995-62-9 2-benzylamino-2-(1-bromoisopropyl)-3-benzyl-5,5-dimethyloxazolidin-4-one 
• 112379-98-3 3-Benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid 1-benzylcarbamoyl-1-methyl-ethyl ester 
• 78877-72-2 3-benzyl-5,5-dimethyl-2-methylamino-2-phenyloxazolidin-4-one 
• 103853-77-6 2-hydroxy-2-methyl-N-benzylpropanamide 
• 142061-49-2 2-(1,2:5,6-di-O-isopropylidene-D-glucofuranos-3-yloxy)-2-methyl-N-benzylpropanamide 
• 128965-94-6 N-Benzyl-2-(biphenyl-4-yloxy)-2-methyl-propionamide 
• 112379-99-4 2-tert-Butoxycarbonylamino-2-methyl-propionic acid 1-benzylcarbamoyl-1-methyl-ethyl ester 
• 91306-14-8 3-benzyl-2-(2-benzyliminopropyl)-2,5,5-trimethyloxazolidin-4-one 
• 91306-19-3 2-acetonyl-5,5-dimethyl-2,3-diphenyloxazolidin-4-one 
• 344584-70-9 3'-benzyl-5,5,5',5'-tetramethyl-3-phenyliminocyclohexanespiro-2'-oxazolidin-4'-one 
• 112379-95-0 2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyric acid 1-benzylcarbamoyl-1-methyl-ethyl ester 

Relevant articles and documents

Visible-Light-Driven Aryl Migration and Cyclization of α-Azido Amides

This paper reports two new visible-light-promoted radical reactions of α-azido amides. By catalysis of [Ir(ppy)2(dtbbpy)]PF6 with i-Pr2NEt as the reducing agent, N-aryl α-azido tertiary amides were first converted to the corresponding aminyl radicals through reduction of the azido group; the aminyl radicals then underwent N-to-N aryl migration to give α-anilinyl-functionalized amides. α-Azido secondary amides, on the other hand, reacted with the solvent ethanol and i-Pr2NEt to afford the imidazolinone products.

Bromo-nitro substitution on a tertiary α carbon - A previously uncharacterized facet of the Kornblum substitution

Sodium nitrite in dimethylformamide substitutes nitro for bromine alpha to an amide carbonyl in high yield at a tertiary site. Hammett plots show a strongly positive ρ value (+0.67), indicating a negatively-charged transition state, in contrast to the typical SN1/SN2 mechanism domain for Kornblum substitutions. 2015

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME

The present invention relates to 7-membered nitrogen-containing heterocyclic compounds and methods of making the same. Using a novel aza-[4+3] cycloaddition reaction, the 7-membered heterocyclic compounds are synthesized by reacting a first reactant and a second reactant. Exemplary first reactants and second reactants include α-halohydroxamates and dienes, respectively.