(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Base Information

Chemical Name:(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester
CAS No.:144156-12-7
Molecular Formula:C₄₀H₄₈ClN₃O₉
Molecular Weight:750.289
Hs Code.:

(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Synonyms:(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

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Chemical Property of (S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

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Technology Process of (S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

There total 6 articles about (S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 144156-12-7
(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

2: 4N HCl / dioxane / 1 h / Ambient temperature

3: NaHCO₃ / tetrahydrofuran; H₂O / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00050a013

Reference yield:

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 144156-12-7
(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaHCO₃ / dimethylformamide / 16 h / 50 °C

2: 100 percent / HCl / dioxane

3: 94 percent / NaBH₃CN / methanol / 1 h / Ambient temperature

4: 95 percent / NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

5: 4N HCl / dioxane / 1 h / Ambient temperature

6: NaHCO₃ / tetrahydrofuran; H₂O / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00050a013

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

: 144156-12-7
(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / HCl / dioxane

2: 94 percent / NaBH₃CN / methanol / 1 h / Ambient temperature

3: 95 percent / NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

4: 4N HCl / dioxane / 1 h / Ambient temperature

5: NaHCO₃ / tetrahydrofuran; H₂O / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jo00050a013