diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

Base Information

Chemical Name:diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate
CAS No.:947695-32-1
Molecular Formula:C₃₁H₄₄N₂O₁₁S
Molecular Weight:652.763
Hs Code.:

diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

Synonyms:diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

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Chemical Property of diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

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Technology Process of diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

There total 7 articles about diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 947695-27-4
diisopropyl 1-{(1R)-1-[(4R,5R)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 947695-32-1
diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;
DOI:10.1055/s-2007-966062

Reference yield:

: 947695-28-5
diisopropyl 1-{(1R)-1-formyl-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

: 947695-32-1
diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 4.35 g / benzene / 20 h / 6 °C

2: 74 percent / osmium tetroxide; N-methylmorpholine N-oxide / H₂O; acetone / 24 h / 20 °C

3: 88 percent / 10-camphorsulfonic acid / acetone / 2 h / 20 °C

4: 85 percent / lithium borohydride / ethanol; tetrahydrofuran / 0 °C

5: 92 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 - 20 °C

With dmap; osmium(VIII) oxide; lithium borohydride; (1S)-10-camphorsulfonic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; benzene; 1: Wittig olefination;
DOI:10.1055/s-2007-966062

Reference yield:

: 947695-30-9
diisopropyl 1-{(1R,2R,3S)-4-ethoxy-2,3-dihydroxy-1-[(4-methoxybenzyl)oxy]methyl-4-oxobutyl}-1,2-hydrazinedicarboxylate

: 947695-32-1
diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 10-camphorsulfonic acid / acetone / 2 h / 20 °C

2: 85 percent / lithium borohydride / ethanol; tetrahydrofuran / 0 °C

3: 92 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 - 20 °C

With dmap; lithium borohydride; (1S)-10-camphorsulfonic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1055/s-2007-966062