diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

Base Information

Chemical Name:diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate
CAS No.:947695-26-3
Molecular Formula:C₂₄H₃₆N₂O₈
Molecular Weight:480.558
Hs Code.:

Synonyms:diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

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Chemical Property of diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

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Technology Process of diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

There total 8 articles about diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 947695-32-1
diisopropyl 1-{(1R)-1-[(4R,5S)-2,2-dimethyl-5-[(4-methylphenyl)sulfonyl]oxymethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

: 947695-26-3
diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1055/s-2007-966062

Reference yield:

: 947695-27-4
diisopropyl 1-{(1R)-1-[(4R,5R)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethyl}-1,2-hydrazinedicarboxylate

: 947695-26-3
diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 - 20 °C

2: 81 percent / sodium hydride / various solvent(s); tetrahydrofuran / 2 h / 20 °C

With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2007-966062

Reference yield:

: 947695-29-6
diisopropyl 1-{(1S,2E)-4-ethoxy-1-[(4-methoxybenzyl)oxy]methyl-4-oxo-2-butenyl}-1,2-hydrazinedicarboxylate

: 947695-26-3
diisopropyl (3aR,4R,7aR)-4-[(4-methoxybenzyl)oxy]methyl-2,2-dimethylperhydro[1,3]dioxolo[4,5-d]pyridazine-5,6-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / osmium tetroxide; N-methylmorpholine N-oxide / H₂O; acetone / 24 h / 20 °C

2: 88 percent / 10-camphorsulfonic acid / acetone / 2 h / 20 °C

3: 85 percent / lithium borohydride / ethanol; tetrahydrofuran / 0 °C

4: 92 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 - 20 °C

5: 81 percent / sodium hydride / various solvent(s); tetrahydrofuran / 2 h / 20 °C

With dmap; osmium(VIII) oxide; lithium borohydride; (1S)-10-camphorsulfonic acid; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1055/s-2007-966062