(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

Base Information

Chemical Name:(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine
CAS No.:182625-84-9
Molecular Formula:C₃₃H₃₅N₅O₆
Molecular Weight:597.671
Hs Code.:

Synonyms:(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

Chemical Property:

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Technology Process of (R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

There total 5 articles about (R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: (R)-glycidyl 4,4'-dimethoxytrityl ether

: 21047-89-2
2-N-isobutyrylguanine

: 182625-84-9
(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jacs.7b02694

Reference yield:

: 10310-21-1
2-amino-6-chloropurine

: 182625-84-9
(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 17 h / 90 °C

2: aq. HCl / 1.25 h / Ambient temperature

3: 1.) TMSCl, pyridine, 3.) aq. NH₄OH, 4.) pyridine

With pyridine; hydrogenchloride; ammonium hydroxide; chloro-trimethyl-silane; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 182625-84-9
(R)-9-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 120 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jacs.7b02694