ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

Base Information

• Chemical Name: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate
• CAS No.: 1420880-39-2
• Molecular Formula: C₄₅H₄₄N₆O₃
• Molecular Weight: 720.851

Synonyms:ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

Chemical Property of ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

There total 8 articles about ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[²H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole (1330277-14-9) + ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (144689-93-0) → ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate (1420880-39-2)

Guidance literature:

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate; With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.333333h; Cooling with ice;

5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

DOI:10.1002/jlcr.2956

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate (1420880-39-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: toluene / 16 h / Reflux

4.1: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Cooling with ice

6.2: 2.5 h / 20 °C

With pyridine; N-Bromosuccinimide; potassium tert-butylate; iodine; magnesium; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

Reference yield:

2,3,5,6-tetra-[2H]-4-bromo toluene (112484-85-2) → ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate (1420880-39-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: toluene / 16 h / Reflux

4.1: triethylamine / dichloromethane / 2.75 h / 20 °C / Cooling with ice

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / Cooling with ice

6.2: 2.5 h / 20 °C

With pyridine; N-Bromosuccinimide; potassium tert-butylate; iodine; magnesium; triethylamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

upstream raw materials:

5-(2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

2,3,5,6-tetra-[²H]-4-bromo toluene

trityl chloride

Downstream raw materials:

ethyl 1-((2,3,5,6-tetra-[²H]-2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

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