1330277-14-9Relevant articles and documents
Synthesis of deuterium-labeled olmesartan and candesartan
Zhang, Chi,Shen, Zucheng,Tian, Lei,Chen, Liqin
, p. 401 - 405 (2013/01/15)
This paper describes the synthesis of deuterium-labeled olmesartan and candesartan. The two desired compounds both used [2H4] 2-cyano-4'-methyl-biphenyl as deuterium-labeled reagent, which was synthesized beforehand in two steps. [2H4] olmesartan was synthesized in six steps further with 17% overall yield, and [2H4] candesartan was synthesized in seven steps further with 13% overall yield. Copyright 2012 John Wiley & Sons, Ltd. This paper describes the synthesis of deuterium-labeled olmesartan and candesartan. The two desired compounds both used [2H4] 2-cyano-4'-methyl-biphenyl as deuterium-labeled reagent, which was synthesized beforehand in two steps. [ 2H4] olmesartan was synthesized in a further six steps with a 17% overall yield, and [2H4] candesartan was synthesized in a further seven steps with a 13% overall yield. Copyright