5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile

Base Information

• Chemical Name: 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile
• CAS No.: 116943-91-0
• Molecular Formula: C₂₀H₁₅N₅O
• Molecular Weight: 341.372
• Mol file: 116943-91-0.mol

Synonyms:5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile

Chemical Property of 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile

There total 2 articles about 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

trimethylsilyl cyanide (7677-24-9) + 6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine (116943-84-1) + benzoyl chloride (98-88-4) → 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile (116943-91-0)

Guidance literature:

aluminium trichloride; In dichloromethane; for 17h; Ambient temperature;

Reference yield:

4-chloro-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (23121-14-4) → 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile (116943-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / PdCl₂, MgO / benzene; methanol

2: 76 percent / AlCl₃ / CH₂Cl₂ / 17 h / Ambient temperature

With hydrogen; aluminium trichloride; magnesium oxide; palladium dichloride; In methanol; dichloromethane; benzene;

Reference yield: 77.0%

5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile (116943-91-0) → 6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine (116943-84-1) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1h; Ambient temperature;

DOI:10.1248/cpb.38.230

upstream raw materials:

trimethylsilyl cyanide

6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine

benzoyl chloride

4-chloro-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

1,2-diphenyl-2-oxoethyl benzoate

6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine

1-phenyl-6-methyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile

(6-Methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-phenyl-methanone