4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Base Information

Chemical Name:4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene
CAS No.:1360569-12-5
Molecular Formula:C₂₁H₂₂BrF₃O
Molecular Weight:427.304
Hs Code.:

Synonyms:4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Suppliers and Price of 4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

There total 9 articles about 4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 1210344-13-0
4-(5-bromo-2-fluorobenzyl)phenol

: 1360568-92-8
(4,4-difluoro-1-methylcyclohexyl)methyl 4-methylbenzenesulfonate

: 1360569-12-5
4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 6h; Inert atmosphere;

Reference yield:

: 588-96-5
4-bromoethoxybenzene

: 1360569-12-5
4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 12 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; boron tribromide; caesium carbonate; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 122665-97-8
4,4-difluorocyclohexanecarboxylic acid

: 1360569-12-5
4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4.1: triethylamine / dmap / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; sulfuric acid; In tetrahydrofuran; N,N-dimethyl-formamide;