methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate

Base Information

• Chemical Name: methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate
• CAS No.: 1032010-93-7
• Molecular Formula: C₁₅H₁₅N₃O₃
• Molecular Weight: 285.302
• Mol file: 1032010-93-7.mol

Synonyms:methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate

Chemical Property of methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate

There total 1 articles about methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzaldehyde (100-52-7) + 3-methyl-2-pyrazoline-5-one (108-26-9) + methyl 2-cyanoacetate (105-34-0) → methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate (1032010-93-7)

Guidance literature:

With methanol; sodium acetate; at 20 ℃; for 1h; Green chemistry;

DOI:10.1016/j.crci.2013.03.003

Reference yield: 69.0%

methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate (1032010-93-7) → methyl (1S*,2R*,3R*)-1-cyano-4-methyl-7-oxo-2-phenyl-5,6-diazaspiro[2.4]-hept-4-ene-1-carboxylate

Guidance literature:

With bromine; sodium ethanolate; In ethanol; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1016/j.mencom.2016.01.008

Reference yield: 61.0%

methyl 2-cyano-3-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-3-phenylpropanoate (1032010-93-7) → methyl (1S*,2R*,3R*)-1-cyano-4-methyl-7-oxo-2-phenyl-5,6-diazaspiro[2.4]hept-4-ene-1-carboxylate

Guidance literature:

With potassium bromide; In methanol; at 20 ℃; Electrolysis;

DOI:10.1016/j.electacta.2015.03.015

upstream raw materials:

benzaldehyde

3-methyl-2-pyrazoline-5-one

methyl 2-cyanoacetate