diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Base Information

• Chemical Name: diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
• CAS No.: 864926-75-0
• Molecular Formula: C₂₂H₂₆N₂O₅S
• Molecular Weight: 430.525

Synonyms:diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Chemical Property of diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Chemical Property:

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Technology Process of diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

There total 4 articles about diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester (24264-33-3) + hydrocinnamic acid chloride (645-45-4) → diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate (864926-75-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 24h;

DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate (864926-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: morpholine; sulfur / ethanol / 20 - 40 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

With morpholine; sulfur; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; 1: Gewald reaction;

DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

N-ethoxycarbonyl-4-piperidone (29976-53-2) → diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate (864926-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: morpholine; sulfur / ethanol / 20 - 40 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

With morpholine; sulfur; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; 1: Gewald reaction;

DOI:10.1016/j.bmcl.2011.09.109

upstream raw materials:

2-amino-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester

hydrocinnamic acid chloride

ethyl 2-cyanoacetate

N-ethoxycarbonyl-4-piperidone

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