(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

Base Information

Chemical Name:(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride
CAS No.:1422013-48-6
Molecular Formula:C₂₀H₂₃N₃O₃*ClH
Molecular Weight:389.882
Hs Code.:

Synonyms:(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

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Chemical Property of (1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

Chemical Property:

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Technology Process of (1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

There total 4 articles about (1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oxime

: 1422013-48-6
(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1016/j.bmcl.2014.02.049

Reference yield:

: 1610546-50-3
1-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}ethanone

: 1422013-48-6
(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; tert.-butylnitrite / tetrahydrofuran / 1 h / 0 - 20 °C / Cooling with ice

2: hydrogenchloride / methanol

With hydrogenchloride; tert.-butylnitrite; potassium tert-butylate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2014.02.049

Reference yield:

: 88915-26-8
4-aminomethyl-1-benzylpiperidine

: 1422013-48-6
(1E)-{6-[(1-benzylpiperidin-4-yl)methoxy]pyridin-3-yl}(oxo)acetaldehyde oximehydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 28 h / 90 °C / Inert atmosphere

2: potassium tert-butylate; tert.-butylnitrite / tetrahydrofuran / 1 h / 0 - 20 °C / Cooling with ice

3: hydrogenchloride / methanol

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert.-butylnitrite; potassium tert-butylate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmcl.2014.02.049