Technology Process of 2-(2-fluoro-6-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 1 articles about 2-(2-fluoro-6-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
toluene;
boronic acid dissolved in toluene; pinacol added; stirred until dissolution; heated to reflux for 1 h; solvent distd. away; purified by column chromy. (silica gel, CH2Cl2-hexanes 10:90); elem. anal.;
DOI:10.1021/om7009792
- Guidance literature:
-
With
isopropylmagnesium chloride*LiCl;
In
tetrahydrofuran;
under Ar; B compd. dissolved in THF; cooled to -78°C (dry ice-EtOH bath); i-PrMgCl*LiCl (1 equiv.) in THF added; soln. of Ph2BiCl (0.8 equiv.) in THF (-78°C) added; rinsed with THF; stirred for 12 h; warmed to room temp.; concd. in vac.; suspended in toluene; filtered through Celite; purified by chromy. (silica gel, EtOAc-hexanes 3:97); recrystd. from CH2Cl2-MeOH at -20°C; elem. anal.;
DOI:10.1021/om7009792
- Guidance literature:
-
With
isopropylmagnesium chloride*LiCl;
In
tetrahydrofuran;
under Ar; B compd. dissolved in THF; cooled to -78°C (dry ice-EtOH bath); i-PrMgCl*LiCl (1 equiv.) in THF added; soln. of BiCl3 (0.8 equiv.) in THF (-78°C) added; rinsed with THF; stirred for 12 h; warmed to room temp.; poured into satd. aq. NH4Cl; extd. with EtOAc; org. layer washed with brine; dried (Na2SO4); filtered; concd. in vac.; recrystd. from CH2Cl2; elem. anal.;
DOI:10.1021/om7009792
